Application of ErbB4 inhibitor in preparation of medicine for treating autism

• Main Authors: MA LIPING, SHEN FENGGE, JIA YUNJIE, DENG YANAN, DU ZIWEI, PANG PANJIAO, ZHANG YINGHUA
• Format: Patent
• Language: Chinese; English
• Published: 26.04.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses application of an ErbB4 inhibitor AG1478 in preparation of drugs for treating autism, according to the application, through establishment of an autism rat model, detection of protein expression of Neuregulin-1 and ErbB4, three-box experiments, repeated stiff behavior detection and learning and memory ability detection, it is found that the Neuregulin-1 and ErbB4 expression of VPA autism model animals is increased; the AG1478 reduces the expression of ErbB4 in an autism-related brain region of a VPA autism model animal, and after an ErbB4 specific inhibitor AG1478 is used for intervention, an NRG1/ErbB4 signal channel is inactivated, and meanwhile, autism-like behavioral abnormality is improved; based on VPA autism model animal social interaction behaviors, social novelty preference behaviors, repeated stiff behaviors and learning and memory ability defects after the NRG1/ErbB4 signal path is inactivated, the animal social interaction behaviors, the social novelty preference behaviors,