N-heterocyclic carbene ligand as well as preparation method and application thereof

• Main Authors: XIA AIBAO, MA AOQIANG, GE MINTONG, XU DANQIAN
• Format: Patent
• Language: Chinese; English
• Published: 19.04.2024
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR RELEVANT APPARATUS; TRANSPORTING

The invention discloses an N-heterocyclic carbene ligand as well as a preparation method and application thereof. According to the ligand, an imidazole compound serves as a main body structure and is coordinated with specific metal to obtain a target complex, the complex can catalyze a selective nitrogen alkylation reaction, and a demonstration reaction is a nitrogen alkylation reaction of piperazine and ethyl alcohol. The method has the advantages of simple reaction system, cheap and easily available raw materials, environmental friendliness, simple post-treatment operation, simple reaction steps, no introduction of other atoms, high atom utilization rate, suitableness for industrial production, and wide application prospect. 本发明公开一种N-杂环卡宾类配体及其制备方法与应用。本发明所述配体是以咪唑类化合物作为主体结构，再与特定金属配位即可得到目标络合物，该络合物可催化选择性氮烷基化反应，示范反应为哌嗪与乙醇的氮烷基化反应。本发明所述反应体系简单、原料价廉易得、环境友好、后处理操作简便，反应步骤简便，不引入其他原子，原子利用率高，适用于工业化生产，具有广阔的应用前景。