Polypeptide inhibitor and application thereof

The present disclosure provides a polypeptide capable of specifically binding to an FAM19A5 protein to inhibit the interaction between an LRRC4 protein family member and the FAM19A5 protein. In some aspects, the polypeptides comprise a FAM19A5 binding domain of a member of the LRRC4 protein family....

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Main Authors KWAK HO-YUN, ZHAO YINHAO, LEE YE RIM, CHO EUN-BEE, KIM HAN-BYUL, SEONG JAE-YOUNG, WU ZE, HA NI, JUNG YONG-WOO, LEE JAE-KEUN, KWON SOON GU, LEE SANG-MYEONG, LEE SOO-HYUN, LEE MIN-HYUK
Format Patent
LanguageChinese
English
Published 12.04.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure provides a polypeptide capable of specifically binding to an FAM19A5 protein to inhibit the interaction between an LRRC4 protein family member and the FAM19A5 protein. In some aspects, the polypeptides comprise a FAM19A5 binding domain of a member of the LRRC4 protein family. The present disclosure also provides methods of promoting the growth of protrusions by administering the polypeptides of the invention. 本公开提供了能够与FAM19A5蛋白特异性结合从而抑制LRRC4蛋白家族成员与FAM19A5蛋白之间相互作用的多肽。在一些方面，所述多肽包含LRRC4蛋白家族成员的FAM19A5结合域。本公开还提供了通过施用本发明所述的多肽促进突起生长的方法。
Bibliography:Application Number: CN202280007063