Cycloalkyl 3-oxopiperazine carboxamides and cycloheteroalkyl 3-oxopiperazine carboxamides as NAV1.8 inhibitors

Novel compounds of structural formula (I) and pharmaceutically acceptable salts thereof are inhibitors of Nav1.8 channel activity and are useful in the treatment, prevention, management, amelioration, control and inhibition of diseases mediated by Nav1.8 channel activity. Compounds of Formula I are...

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Main Authors BELL IAN M, SHAH ANKUR A, ARASAPPAN ASHOK, VAN HEYST, MARC, D, LIU HONG, LIU JIAN, COX JASON M, KELLY, MICHAEL, J., III, LAYTON MARK E
Format Patent
LanguageChinese
English
Published 12.04.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Novel compounds of structural formula (I) and pharmaceutically acceptable salts thereof are inhibitors of Nav1.8 channel activity and are useful in the treatment, prevention, management, amelioration, control and inhibition of diseases mediated by Nav1.8 channel activity. Compounds of Formula I are useful for treating, preventing or managing pain disorders, cough disorders, acute pruritus disorders, and chronic pruritus disorders. # imgabs0 # 结构式(I)的新颖化合物及其药学上可接受的盐是Nav1.8通道活性的抑制剂，并且可用于治疗、预防、管理、改善、控制和抑制由Nav1.8通道活性介导的疾病。式I的化合物可用于治疗、预防或管理疼痛病症、咳嗽病症、急性瘙痒病症和慢性瘙痒病症。#imgabs0#
Bibliography:Application Number: CN202280048071