Pharmaceutical composition for preventing or treating cancer

• Main Authors: CHEONG JAE-HO, HWANG SUNG-SOON, KIM JAE-WOO, YOON BOKYUNG, KIM HYUN-HEE
• Format: Patent
• Language: Chinese; English
• Published: 12.04.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The present invention relates to a method for preventing, ameliorating or treating a cancer patient, in particular an Epithelial Mesenchymal Transformation (EMT) subtype cancer patient, in which the expression level of a Glutaminase (GLS) gene or a protein encoded by the GLS gene is increased, and to a method for preventing, ameliorating or treating a cancer patient, in particular an Epithelial Mesenchymal Transformation (EMT) subtype cancer patient, in which the expression level of the GLS gene or the protein encoded by the GLS gene is increased. When a phosphoglycerate dehydrogenase (PHGDH), a serine hydroxymethyltransferase (SHMT), and a methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor are administered in combination, 1C metabolism is more effectively inhibited, and the composition has a synergistic effect of inhibiting cancer cell proliferation in patients with recurrence, metastasis, and refractory cancers which are difficult to treat due to drug resistance of anti-cancer agents, and can be u