Metabolic marker for clinical early diagnosis of smoke disease and application of metabolic marker

• Main Authors: TENG YONGSHI, LIU HUIQIN, YU SHAN, LI WEI, QIN LINGZHI, HE YANBIN
• Format: Patent
• Language: Chinese; English
• Published: 12.04.2024
• Subjects: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; PHYSICS

According to the metabolic marker for smoke disease clinical early diagnosis and the application of the metabolic marker, serum samples of clinically defined smoke disease patients and healthy people are collected, serum non-targeted metabonomics detection is carried out, differential metabolites which have the highest diagnostic value and can diagnose the smoke disease occurrence risk in the early stage are screened out, and therefore the smoke disease clinical early diagnosis effect is achieved. And a differential diagnosis model composed of a plurality of metabolites is constructed and is used for effectively diagnosing the early smoke disease, so that the early smoke disease patients can be accurately identified and diagnosed, early discovery and early intervention are facilitated, early discovery and early treatment of the smoke disease are promoted, and the urgent clinical requirements are met. 本发明提供了一种用于烟雾病临床早期诊断的代谢标志物及其应用，通过采集临床上定义的烟雾病患者和健康人群的血清样本，进行血清非靶向代谢组学检测，筛选出诊断价值最高、能早期诊断烟雾病发生风险的差异代谢物，并构建联合多个代谢物组