Recombinant XVII type collagen and expression system thereof

• Main Authors: CHEN JIAYUE, LIN XIAOMEI, LIU YUANKUN
• Format: Patent
• Language: Chinese; English
• Published: 12.04.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS; SPIRITS; VINEGAR; WINE

The invention provides a recombinant XVII type collagen and an expression system thereof, and belongs to the technical field of cosmetic raw material development. According to the invention, by designing and splicing the sequence of the human-derived XVII type collagen, two recombinant XVII type collagens are obtained, and the problem that the performance of the recombinant XVII type collagen needs to be improved in the prior art is solved. The recombinant XVII type collagen provided by the invention has better anti-aging and wrinkle-removing effects, and can exert excellent effects at a low concentration. Experiments prove that the recombinant XVII type collagen provided by the invention has the effects of promoting skin cell proliferation and trophoblast cell growth, and can promote collagen synthesis, so that the effects of resisting aging and removing wrinkles are achieved; the recombinant XVII type collagen can be absorbed to a corium layer and has the effect of obviously increasing the thickness of the