Naphthalene compound as well as preparation method and medical application thereof

The invention discloses a naphthalene compound as well as a preparation method and medical application thereof. The invention provides the naphthalene compound as shown in a formula (I) or pharmaceutically acceptable salt, ester, stereoisomerism, deuterated compound or solvate thereof. The compound...

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Main Authors DAI LIANG, WEN XIAOAN, YUAN HAOLIANG, CHEN CAIPING, ZHANG FENGYI, XU QINGLONG, ZHU HUAYUN, LIANG ZIJIANG, FENG ZHIQI, SUN HONGBIN, ZHANG XIAN, TAN SHUDAN, LIU LIU, CHEN QI, WANG DALIN, ZHANG HONGHAN, CHEN DI
Format Patent
LanguageChinese
English
Published 12.04.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention discloses a naphthalene compound as well as a preparation method and medical application thereof. The invention provides the naphthalene compound as shown in a formula (I) or pharmaceutically acceptable salt, ester, stereoisomerism, deuterated compound or solvate thereof. The compound or the pharmaceutically acceptable salt, ester, deuterated compound, stereoisomer or solvate thereof can inhibit the activity of USP7 enzyme, and can be used for preparing medicines for treating USP7-mediated diseases. # imgabs0 # 本发明公开了萘类化合物及其制备方法和医药用途，本发明提供如式(I)所示的萘类化合物或其药学上可接受的盐、酯、立体异构、氘代物或溶剂化物。本发明化合物或其药学上可接受的盐、酯、氘代物、立体异构体或溶剂化物能抑制USP7酶的活性，可以制备用于治疗USP7介导的疾病的药物。#imgabs0#
Bibliography:Application Number: CN202410068136