Indane compound as well as preparation method and medical application thereof

• Main Authors: DAI LIANG, WEN XIAOAN, YUAN HAOLIANG, CHEN CAIPING, ZHANG FENGYI, XU QINGLONG, ZHU HUAYUN, LIANG ZIJIANG, FENG ZHIQI, SUN HONGBIN, ZHANG XIAN, TAN SHUDAN, LIU LIU, CHEN QI, WANG DALIN, ZHANG HONGHAN, CHEN DI
• Format: Patent
• Language: Chinese; English
• Published: 12.04.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention discloses an indan compound as well as a preparation method and medical application thereof. The invention provides the indan compound as shown in a formula (I) or pharmaceutically acceptable salt, ester, stereoisomer, deuterated compound or solvate thereof. The compound or the pharmaceutically acceptable salt or stereoisomer or deuterated compound or solvate thereof has excellent USP7 enzyme inhibition activity, and can be used for preparing medicines for preventing or treating USP7 mediated diseases. # imgabs0 # 本发明公开了茚满类化合物及其制备方法和医药用途，本发明提供如式(I)所示的茚满类化合物或其药学上可接受的盐、酯、立体异构、氘代物或溶剂化物。本发明化合物或其药学上可接受的盐或立体异构体或氘代化物或溶剂化物具有优异的抑制USP7酶的活性，可以用制备预防或治疗USP7介导的疾病的药物。#imgabs0#