Formononetin derivative as well as preparation method, pharmaceutical composition and application thereof

• Main Authors: ZHU YANBO, CAI ENBO, HAN JIAHONG, ZHAO YAN, SU FENGYAN, WANG XINXIN, CUI HUANJIE
• Format: Patent
• Language: Chinese; English
• Published: 12.04.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides a formononetin derivative as well as a preparation method, a pharmaceutical composition and application thereof, and belongs to the technical field of medicines. The formononetin derivative provided by the invention has a good anti-tumor effect, the anti-tumor effect of most derivatives is superior to that of a positive control drug 5 fluorouracil, especially a compound 3, the formononetin derivative has a good proliferation inhibition effect on human gastric cancer cells HGC-27 and human non-small cell lung cancer cells A945, and the IC50 values are 4.77 +/-0.29 mu M and 4.95 +/-1.38 mu M respectively. Meanwhile, in the 18 prepared derivatives, the proliferation inhibition effect of 7 compounds on human breast cancer cells MCF-7 is improved compared with that of formononetin, the proliferation inhibition effect of the 7 compounds is superior to that of a positive control drug 5-fluorouracil, the compound 1 has the strongest proliferation inhibition effect on the human breast cancer cel