Modulators of cystic fibrosis transmembrane conductance modulators, pharmaceutical compositions, methods of treatment and methods of making same

• Main Authors: HADIDA RUAH SARA SABINA, ZHOU JIANGUO, MCCARTNEY JASON, SHI YI, HSIA CLARA KANG-JEN, HUGHES ROBERT M, WU JIE, PARASELLI PRASUNA, PIERRE FABRICE JEAN DENIS, KHATUYA, HARPREET, GROSS RAYMOND SCOTT, FERRIS LORI A, BECKER MARC, GROOTENHUIS PETER DIEDERIK JACOBUS, KRENITSKY PAUL JOHN, VAN GOOR FREDERIK FRANK, JOSHI PRAMOD V, ANDERSEN CARSTEN, KESHAVARZ-SHOKRI ALI, STAVROPOULOS KATHY, ANGELL PAUL T, CLEVELAND THOMAS, ALCACIO TIMOTHY, ABELA ALEXANDER RUSSELL, TERMIN ANDREAS PETER, KANG PING, SCHIECHEL DAVID A, YOUNG TIMOTHY J, MILLER MARK T, SHRESTHA MONA, GUREVICH ANTON, CLEMENS JEREMY J
• Format: Patent
• Language: Chinese; English
• Published: 09.04.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed herein are compounds of Formula (I): # imgabs0 # a pharmaceutically acceptable salt thereof, a deuterated derivative of any one of the foregoing, and a metabolite of any one of the foregoing. Also disclosed herein are pharmaceutical compositions comprising the foregoing, methods of treating cystic fibrosis using the foregoing, and methods of making the foregoing. Also disclosed herein are solid state forms of Compound 1 and salts and solvates thereof. 本文公开式(I)化合物，#imgabs0#其药学上可接受的盐、上述任一者的氘化衍生物和上述任一者的代谢物。本文还公开包含上述各项的药物组合物、使用上述各项来治疗囊性纤维化的方法和制备上述各项的方法。本文还公开化合物1及其盐和溶剂合物的固态形式。