Preparation and application of triazole anti-tumor inhibitor

• Main Authors: WANG FENGGE, YE ZI, ZHANG CHONGJING, XU SHIQI
• Format: Patent
• Language: Chinese; English
• Published: 09.04.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to preparation and application of a triazole anti-tumor inhibitor. The invention relates to a 5-chloromethyl-1, 2, 4-triazole-3-sulfydryl derivative, and belongs to the technical field of medicines. Intermediates required for synthesizing the compounds can be used for simultaneously synthesizing compounds with different substitutions on 2-site N atoms or 3-site S atoms through a one-pot method, and the compounds can be respectively and continuously derivatized to obtain target compounds. The compound disclosed by the invention has a good in-vitro inhibition effect on human tumor cells and has potential practical application value. 一类三氮唑类抗肿瘤抑制剂的制备和应用。本发明涉及一类5-氯甲基-1,2,4三氮唑-3-巯基衍生物，属于医药技术领域。合成此类化合物所需中间体可通过一锅法同时合成在2位N原子或3位S原子上不同取代的化合物，并可分别继续衍生化得到目标化合物。本发明的化合物对人肿瘤细胞体外抑制效果良好，具有潜在的实际应用价值。