Novel method for preparing antibody-drug conjugates

The present invention relates to a novel method for preparing antibody-drug conjugates. A method for producing a compound represented by formula (C) wherein R1 represents an amino group protected by a protecting group, the method comprising a step of subjecting a compound represented by formula (B)...

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Bibliographic Details
Main Authors TAKEDA TADAHIRO, SAKANISHI KOHEI, NOGUCHI SHIGERU, HITOSHI YOSHIO
Format Patent
LanguageChinese
English
Published 09.04.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention relates to a novel method for preparing antibody-drug conjugates. A method for producing a compound represented by formula (C) wherein R1 represents an amino group protected by a protecting group, the method comprising a step of subjecting a compound represented by formula (B) to intramolecular cyclization to convert the compound into the compound represented by formula (C) wherein R1 represents the same meaning as described above. # imgabs0 # 本发明涉及制备抗体-药物缀合物的新方法。式(C)表示的化合物的制备方法，其中R1表示被保护基团保护的氨基，所述方法包括使式(B)表示的化合物进行分子内环化以将该化合物转化为式(C)表示的化合物的步骤，其中R1表示与上述相同的含义。#imgabs0#
Bibliography:Application Number: CN202410018861