Novel bifunctional heterocyclic compound having bruton's tyrosine kinase decomposition effect through ubiquitin proteasome pathway and use thereof
The present invention relates to a novel heterocyclic compound for preventing or treating cancer, autoimmune diseases, and inflammatory diseases, and a composition comprising the same, the novel heterocyclic compound of the present invention being a bifunctional compound which has a Bruton's ty...
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Format | Patent |
Language | Chinese English |
Published |
05.04.2024
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Abstract | The present invention relates to a novel heterocyclic compound for preventing or treating cancer, autoimmune diseases, and inflammatory diseases, and a composition comprising the same, the novel heterocyclic compound of the present invention being a bifunctional compound which has a Bruton's tyrosine kinase (BTK) decomposition effect through the ubiquitin proteasome pathway, and which can be used for preventing or treating cancer, autoimmune diseases, and inflammatory diseases, and a composition comprising the same, and the novel heterocyclic compound of the present invention being a bifunctional compound having a Bruton's tyrosine kinase (BTK) decomposition effect through the ubiquitin proteasome pathway. The composition can be effectively used as a composition for preventing or treating cancer, autoimmune diseases and Parkinson's disease.
本发明涉及一种新型杂环化合物及包含其的组合物,其用于预防或治疗癌症、自身免疫疾病及炎症性疾病,本发明的新型杂环化合物是一种双功能化合物,其通过泛素蛋白酶体途径,具有布鲁顿酪氨酸激酶(Bruton's tyrosine kinase,BTK)分解作用效果,可有效地用作用于预防或治疗癌症、自身免疫疾病及帕金森病的组合物。 |
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AbstractList | The present invention relates to a novel heterocyclic compound for preventing or treating cancer, autoimmune diseases, and inflammatory diseases, and a composition comprising the same, the novel heterocyclic compound of the present invention being a bifunctional compound which has a Bruton's tyrosine kinase (BTK) decomposition effect through the ubiquitin proteasome pathway, and which can be used for preventing or treating cancer, autoimmune diseases, and inflammatory diseases, and a composition comprising the same, and the novel heterocyclic compound of the present invention being a bifunctional compound having a Bruton's tyrosine kinase (BTK) decomposition effect through the ubiquitin proteasome pathway. The composition can be effectively used as a composition for preventing or treating cancer, autoimmune diseases and Parkinson's disease.
本发明涉及一种新型杂环化合物及包含其的组合物,其用于预防或治疗癌症、自身免疫疾病及炎症性疾病,本发明的新型杂环化合物是一种双功能化合物,其通过泛素蛋白酶体途径,具有布鲁顿酪氨酸激酶(Bruton's tyrosine kinase,BTK)分解作用效果,可有效地用作用于预防或治疗癌症、自身免疫疾病及帕金森病的组合物。 |
Author | LEE SONG-HEE HA JAE DU HWANG JONG YEON CHO SUNG YUN KIM HYUN-JIN LEE HO-HYUN KIM PIL HO MOON HEE-JUNG KIM HAN-WOOL PARK JI-HOON IM YE-SEUL PARK JI YOON AHN, JEONG MIN YOO SUN-MI XU FANSHAN RYU, JE HO |
Author_xml | – fullname: PARK JI YOON – fullname: LEE HO-HYUN – fullname: KIM HYUN-JIN – fullname: KIM HAN-WOOL – fullname: PARK JI-HOON – fullname: YOO SUN-MI – fullname: LEE SONG-HEE – fullname: HA JAE DU – fullname: IM YE-SEUL – fullname: XU FANSHAN – fullname: AHN, JEONG MIN – fullname: CHO SUNG YUN – fullname: KIM PIL HO – fullname: HWANG JONG YEON – fullname: MOON HEE-JUNG – fullname: RYU, JE HO |
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DocumentTitleAlternate | 通过泛素蛋白酶体途径具有布鲁顿酪氨酸激酶分解作用的新型双功能杂环化合物及其用途 |
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Snippet | The present invention relates to a novel heterocyclic compound for preventing or treating cancer, autoimmune diseases, and inflammatory diseases, and a... |
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Title | Novel bifunctional heterocyclic compound having bruton's tyrosine kinase decomposition effect through ubiquitin proteasome pathway and use thereof |
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