Novel bifunctional heterocyclic compound having bruton's tyrosine kinase decomposition effect through ubiquitin proteasome pathway and use thereof

• Main Authors: PARK JI YOON, LEE HO-HYUN, KIM HYUN-JIN, KIM HAN-WOOL, PARK JI-HOON, YOO SUN-MI, LEE SONG-HEE, HA JAE DU, IM YE-SEUL, XU FANSHAN, AHN, JEONG MIN, CHO SUNG YUN, KIM PIL HO, HWANG JONG YEON, MOON HEE-JUNG, RYU, JE HO
• Format: Patent
• Language: Chinese; English
• Published: 05.04.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a novel heterocyclic compound for preventing or treating cancer, autoimmune diseases, and inflammatory diseases, and a composition comprising the same, the novel heterocyclic compound of the present invention being a bifunctional compound which has a Bruton's tyrosine kinase (BTK) decomposition effect through the ubiquitin proteasome pathway, and which can be used for preventing or treating cancer, autoimmune diseases, and inflammatory diseases, and a composition comprising the same, and the novel heterocyclic compound of the present invention being a bifunctional compound having a Bruton's tyrosine kinase (BTK) decomposition effect through the ubiquitin proteasome pathway. The composition can be effectively used as a composition for preventing or treating cancer, autoimmune diseases and Parkinson's disease. 本发明涉及一种新型杂环化合物及包含其的组合物，其用于预防或治疗癌症、自身免疫疾病及炎症性疾病，本发明的新型杂环化合物是一种双功能化合物，其通过泛素蛋白酶体途径，具有布鲁顿酪氨酸激酶(Bruton's tyrosine kinase，BTK)分解作用效果，可有效地用作用于预防或治疗癌症、自身免疫疾病及帕金森病的组合物。