Heparin-protamine compound coated gold nanocluster and preparation method thereof

The invention belongs to the technical field of biochemistry and nanometer materials, and particularly relates to a heparin-protamine compound coated gold nanocluster and a preparation method thereof. The method is characterized in that mixed sulfhydrylated heparin and protamine form a compound, chl...

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Bibliographic Details
Main Authors YANG LUQI, LI JIN'AO, HUANG FANG, WANG XIAOJUAN, QI ZICHUN, WEI YIFAN, LU YUHANG
Format Patent
LanguageChinese
English
Published 05.04.2024
Subjects
CASTING
MAKING METALLIC POWDER
MANUFACTURE OF ARTICLES FROM METALLIC POWDER
PERFORMING OPERATIONS
POWDER METALLURGY
TRANSPORTING
WORKING METALLIC POWDER
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Summary:The invention belongs to the technical field of biochemistry and nanometer materials, and particularly relates to a heparin-protamine compound coated gold nanocluster and a preparation method thereof. The method is characterized in that mixed sulfhydrylated heparin and protamine form a compound, chloroauric acid is reduced in the compound through a hydrothermal method, and gold nanoclusters grow in situ. The heparin-protamine compound has triple functions of forming a stable dispersion system to enable the gold nanocluster growing in the heparin-protamine compound to have good water solubility, reducing chloroauric acid and forming a gold-sulfur bond anchored gold nanocluster, and selectively degrading the heparin-protamine compound by trypsin to cause fluorescence change of the gold nanocluster. The gold nanocluster prepared by the invention and the heparin-protamine compound coated by the gold nanocluster form particles with the diameter of 30-50nm, and the particles have stronger fluorescence emission in t
Bibliography:Application Number: CN202410027288