Near-infrared fluorescent probe, preparation method thereof and application of near-infrared fluorescent probe in dual-response detection of Cu < 2 + > and A < beta > aggregate
The invention belongs to the field of analysis and detection, and relates to a small-molecule fluorescent probe, in particular to a near-infrared fluorescent probe, a preparation method thereof and application of the near-infrared fluorescent probe in dual-response detection of Cu < 2 + > and...
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Main Authors | , , , |
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Format | Patent |
Language | Chinese English |
Published |
02.04.2024
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Subjects | |
Online Access | Get full text |
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Summary: | The invention belongs to the field of analysis and detection, and relates to a small-molecule fluorescent probe, in particular to a near-infrared fluorescent probe, a preparation method thereof and application of the near-infrared fluorescent probe in dual-response detection of Cu < 2 + > and A < beta > aggregates. The probe is modified on a fluorophore of a rhodamine derivative, so that the emission wavelength of the rhodamine derivative is subjected to red shift towards a near-infrared region. The name of the fluorescent probe is (E)-2-amino-6 '-(diethylamino)-4'-(4-(piperidine-1-yl) benzylidene)-1 ', 2', 3 ', 4'-tetrahydrospiro [isoindoline-1, 9 '-xanthene]-3-ketone, and the fluorescent probe has the outstanding characteristics that the fluorescent probe can be used for simultaneously detecting Cu < 2 + > and A < beta > aggregates in the Alzheimer's disease (AD), the preparation method is simple, the operation is easy, the cost is low, and the fluorescent probe is suitable for industrial production. The ne |
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Bibliography: | Application Number: CN202311821356 |