Near-infrared fluorescent probe, preparation method thereof and application of near-infrared fluorescent probe in dual-response detection of Cu < 2 + > and A < beta > aggregate

• Main Authors: WANG BINGXIN, ZHANG ZHIKANG, YAN LIN, MA YUNMENG
• Format: Patent
• Language: Chinese; English
• Published: 02.04.2024
• Subjects: ADHESIVES; CHEMISTRY; DYES; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; NATURAL RESINS; ORGANIC CHEMISTRY; PAINTS; PHYSICS; POLISHES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; TESTING

The invention belongs to the field of analysis and detection, and relates to a small-molecule fluorescent probe, in particular to a near-infrared fluorescent probe, a preparation method thereof and application of the near-infrared fluorescent probe in dual-response detection of Cu < 2 + > and A < beta > aggregates. The probe is modified on a fluorophore of a rhodamine derivative, so that the emission wavelength of the rhodamine derivative is subjected to red shift towards a near-infrared region. The name of the fluorescent probe is (E)-2-amino-6 '-(diethylamino)-4'-(4-(piperidine-1-yl) benzylidene)-1 ', 2', 3 ', 4'-tetrahydrospiro [isoindoline-1, 9 '-xanthene]-3-ketone, and the fluorescent probe has the outstanding characteristics that the fluorescent probe can be used for simultaneously detecting Cu < 2 + > and A < beta > aggregates in the Alzheimer's disease (AD), the preparation method is simple, the operation is easy, the cost is low, and the fluorescent probe is suitable for industrial production. The ne