Novel sodium alginate antibacterial hydrogel material as well as preparation method and application thereof

• Main Authors: REN KEFENG, ZHANG JIEXUAN, JI JIAN
• Format: Patent
• Language: Chinese; English
• Published: 02.04.2024
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; DERIVATIVES THEREOF; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; GENERAL PROCESSES OF COMPOUNDING; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; POLYSACCHARIDES; THEIR PREPARATION OR CHEMICAL WORKING-UP; USE OF INORGANIC OR NON-MACROMOLECULAR ORGANIC SUBSTANCES ASCOMPOUNDING INGREDIENTS; WORKING-UP

The invention relates to the technical field of biological medicines, and discloses a novel sodium alginate antibacterial hydrogel material as well as a preparation method and application thereof. The preparation method comprises the following steps: 1, adding a catalyst into a sodium alginate solution, mixing, adding dopamine, reacting, and purifying and drying a product to obtain SA-DA; step 2, dissolving SA-DA, adding dopamine, and carrying out polymerization reaction under an alkaline condition to obtain an SA-DA (at) PDA precursor solution; and step 3, adding a CaCO3 suspension and D-(+) gluconic acid delta-lactone into the SA-DA (at) PDA precursor solution, mixing, and curing to obtain the novel alginic acid antibacterial hydrogel material. According to the invention, sodium alginate is used as a base material, a multi-crosslinked hydrogel material is obtained through dopamine grafting, dopamine self-polymerization and calcium carbonate crosslinking, and the material not only has excellent biocompatibil