Nano-drug for regulating macrophage M2 type polarization by targeting mitochondria as well as preparation method and application of nano-drug

• Main Authors: ZHOU WENHONG, LIU YUYU, WANG GUANHAI, GUO NING, CUI LIAO, CHEN JIA, LIU YUN
• Format: Patent
• Language: Chinese; English
• Published: 02.04.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the technical field of nano-drug materials for treating rheumatoid arthritis, and particularly relates to a nano-drug for regulating macrophage M2 type polarization by targeting mitochondria as well as a preparation method and application of the nano-drug. According to the nano-drug, a porous material which is relatively mature at present is used as a main carrier, and an anti-inflammatory drug is loaded into the porous material; meanwhile, the natural polyphenol modified by folic acid and 4-carboxybutyl triphenylphosphonium bromide and high-valence metal ions are subjected to a complexation reaction to form a metal-polyphenol grid structure, and the porous material loaded with the anti-inflammatory drug is packaged to prepare the anti-inflammatory drug. Wherein the folic acid can be recognized by a folic acid receptor expressed by activated macrophages, so that the nano system is swallowed into cells; the effect of treating rheumatoid arthritis through targeted mitochondrial regulati