Application of IL-28A in preparation of medicine for treating colon cancer/colitis

• Main Authors: ZHANG JUNFENG, ZHANG HUI, CHENG DALEI
• Format: Patent
• Language: Chinese; English
• Published: 02.04.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides an application of IL-28A in preparation of a medicine for treating colon cancer/colitis, and belongs to the technical field of biological medicine.In an AOM + DSS model, compared with a wild type mouse (IL-28AWT) group, colon tumors of IL-28A gene knockout (IL-28A-/-) mice grow more quickly, the number of the tumors is larger, and the colon cancer/colitis can be better treated. Meanwhile, whether the IL-28A has an inhibiting effect on the development of mouse colitis diseases or not is also researched, and the result shows that the IL-28A can inhibit acute enteritis of mice. Furthermore, the invention finds that IL-28A directly inhibits differentiation and recruitment of MDSCs by activating an IL-28A receptor expressed by MDSCs, and plays a key regulation role in occurrence and development of colon cancer. Therefore, the invention reveals that IL-28A can significantly inhibit colon cancer/colitis for the first time. The invention provides a new drug choice for clinical diagnosis and tre