Preparation and application of bistetrahydroisoquinoline derivative with cyclic N, O-hemiacetal amine

• Main Authors: YAO ZHUJUN, WANG MIN, XI JIE
• Format: Patent
• Language: Chinese; English
• Published: 29.03.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention belongs to the field of medicinal chemistry, and particularly relates to preparation and application of a bistetrahydroisoquinoline derivative with cyclic N, O-hemiacetal amine, the bistetrahydroisoquinoline derivative with cyclic N, O-hemiacetal amine is simple in preparation method and novel in structure, shows good in-vitro anti-proliferative activity on various human-derived cancer cells, and can be used for preparing a novel anti-proliferative drug. A novel structural design idea is provided for potential DNA alkylation reagents, and a novel scheme is provided for research and development of bistetrahydroisoquinoline anti-cancer drugs. 本发明属于药物化学领域，具体涉及一种具有环状N,O-半缩醛胺的双四氢异喹啉衍生物的制备及用途，该类具有环状N,O-半缩醛胺的双四氢异喹啉衍生物制备方法简单，结构新颖，对多种人源癌细胞表现出了良好的体外抗增殖活性，为潜在的DNA烷基化试剂提供了新的结构设计思路，为双四氢异喹啉类抗癌药物的研究与发展提供了新的方案。