Enrofloxacin nanosuspension as well as preparation method and application thereof

• Main Authors: LI XINGYE, WANG YAN
• Format: Patent
• Language: Chinese; English
• Published: 29.03.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the technical field of veterinary drugs, and provides an enrofloxacin nanosuspension as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing chitosan oligosaccharide, citral and an alcohol-water mixed solvent for condensation reaction to obtain a chitosan oligosaccharide-citral derivative; the preparation method comprises the following steps: mixing a chitosan oligosaccharide-citral derivative, enrofloxacin, an adhesive, a suspending aid and water, and shearing to obtain a primary suspension; and homogenizing the primary suspension, so as to obtain the enrofloxacin nano suspension. The chitosan oligosaccharide-citral derivative is adopted as a shell material to coat enrofloxacin, and the obtained nanosuspension is good in taste masking effect and stable in property, has a slow and controlled release characteristic, can effectively solve the problem that the food consumption of animals is reduced, ensures the effective bacte