Allochromenone inhibitors of phosphoinositide 3-kinase (PI3K) for treatment of disease

• Main Authors: DAVADI, SRIDHAR, ARONOV SERGEY DMITRIEVICH, KOLAKOWSKI GABRIELLE R, LONG KEVIN FRANKLIN, POTOCHNIG, GEORGE, M, KNIGHT, JOSEPH, L, MEYNE CHRISTOPHER G, ANDERSON ERIK D, HICKEY, EUGENE, R, IRWIN TIMOTHY C, KESICKI, EDMUND, A, WELCH, MICHAEL, B, WIJAJA THOMAS, KUMAR MUKESH, CHEN XIAOHONG, WANG HUAYU, BOYLES NICHOLAS A, MCCLAIN JAMES A
• Format: Patent
• Language: Chinese; English
• Published: 26.03.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure relates to compounds of Formula (I): Formula (I) or a pharmaceutically acceptable salt thereof, wherein R, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein, as allochromenone inhibitors of phosphoinositide 3-kinase (PI3K), useful in the treatment of diseases or disorders associated with PI3K modulation. The present disclosure also relates to methods of making and using a compound of Formula (I) or a pharmaceutically acceptable salt thereof. # imgabs0 # 本公开内容涉及作为磷酸肌醇3-激酶(PI3K)的变构色烯酮抑制剂的、可用于治疗与PI3K调节相关的疾病或障碍的式(I)的化合物，式(I)或其药学上可接受的盐，其中R、R1、R2、R3、R4、R5、R6、R7和R8如本文中定义。本公开内容还涉及制备和使用式(I)的化合物或其药学上可接受的盐的方法。#imgabs0#