Amphiphilic ionic polymer modified resin microspheres as well as preparation method and application thereof

• Main Authors: CHEN XIAOJING, YANG ZHENGGEN, LIN ZHENNAN, XU LINGYAN, CHEN XIAOYUAN, AN HONGTAO
• Format: Patent
• Language: Chinese; English
• Published: 26.03.2024
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY; GENERAL PROCESSES OF COMPOUNDING; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; THEIR PREPARATION OR CHEMICAL WORKING-UP; THEIR RELEVANT APPARATUS; TRANSPORTING; WORKING-UP

The invention belongs to the technical field of medical materials, and particularly relates to amphiphilic ionic polymer modified resin microspheres as well as a preparation method and application thereof. The amphiphilic ionic polymer modified resin microsphere comprises a resin microsphere and an amphiphilic ionic polymer grafted on the surface of the resin microsphere, the surface of the resin microsphere contains hanging double bonds, the amphiphilic ionic polymer is polybetaine, and the polymerization degree of the amphiphilic ionic polymer is 2-50; the amphiphilic ionic polymer polybetaine with the polymerization degree of 2-50 is grafted on the surface of the resin microsphere, so that the structure of the modified resin microsphere is stable, the biocompatibility and hydrophilicity of the resin microsphere are improved, meanwhile, the adsorption performance of the resin microsphere on pathogenic factors is kept, and the modified resin microsphere can be used for preparing a blood purification device,