Method for photocatalytic synthesis of tetracyclic quinazolinone under metal-free condition

The invention discloses a method for photocatalytic synthesis of tetracyclic quinazolinone under a metal-free condition, which comprises the following steps: in a glass reaction container, adding different types of substrates N-acyl-N-(2-bromobenzyl) aminonitrile according to a ratio, carrying out a...

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Bibliographic Details
Main Authors TAN WENJIAN, HUANGFANG PING, YANG KUN, WANG KAI, TENG QINGHU, PAN XINYAO
Format Patent
LanguageChinese
English
Published 26.03.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention discloses a method for photocatalytic synthesis of tetracyclic quinazolinone under a metal-free condition, which comprises the following steps: in a glass reaction container, adding different types of substrates N-acyl-N-(2-bromobenzyl) aminonitrile according to a ratio, carrying out a reaction for 1-2 hours by using N, N-diisopropylethylamine as an additive and 2, 4, 5, 6-tetradiphenylamine isophthalonitrile (4-DPAIPN) as a catalyst, and carrying out a reaction for 1-2 hours at the temperature of 50-60 DEG C to obtain the tetracyclic quinazolinone. The tetracyclic quinazolinone derivative is prepared by taking tetracyclic quinazolinone as a raw material, taking acetonitrile as a solvent, performing irradiation reaction for 8 hours by two blue LED (450-460nm) lamps at 68 DEG C in a nitrogen atmosphere, and performing column chromatography separation and purification on a crude product. The 2-bromobenzylamine which is low in price and easy to obtain is used as the raw material, the use of a noble
Bibliography:Application Number: CN202311564266