High-water-solubility cationic cyclodextrin derivative as well as preparation method and application thereof

• Main Authors: SHI LUQIU, LI LI, XUE HONGYU, ZHANG SHASHA, LI HUASHAN
• Format: Patent
• Language: Chinese; English
• Published: 22.03.2024
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; DERIVATIVES THEREOF; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; POLYSACCHARIDES; THEIR PREPARATION OR CHEMICAL WORKING-UP

The invention discloses a high-water-solubility cationic cyclodextrin derivative as well as a preparation method and application thereof. The cationic cyclodextrin derivative takes amino acid as a linking group to link alpha/gamma-cyclodextrin and a water-soluble cationic group. The cationic cyclodextrin derivative is synthesized by the following steps: firstly, taking alpha/gamma-cyclodextrin as a starting raw material, and preparing alpha/gamma-cyclodextrin sulfonate by adopting sulfonyl chloride; then, carrying out nucleophilic reaction on the sulfonate-alpha/gamma-cyclodextrin and amino groups or hydroxyl groups on amino acid to prepare amino acid-cyclodextrin; and finally, carrying out ring-opening reaction on the epoxypropyl cationic compound and residual amino groups or hydroxyl groups on amino acid to obtain the water-soluble cationic cyclodextrin derivative. The high-water-solubility cationic cyclodextrin derivative can be applied to the fields of daily chemicals, textile printing and dyeing, drug ca