Composition for cartilage regeneration comprising HAPLN1 as active ingredient

• Main Authors: JANG JI-MIN, KIM DAE-KYUNG
• Format: Patent
• Language: Chinese; English
• Published: 22.03.2024
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a composition for cartilage regeneration comprising HAPLN1 as an active ingredient, according to the present invention, the HAPLN1 protein has the ability to promote cartilage formation and articular cartilage regeneration, and can increase the composition ratio of cells having cartilage formation ability and induce cartilage tissue regeneration by increasing the expression level of TGF-beta receptor I in cartilage cells. Therefore, the HAPLN1 protein of the present invention can be effectively used as a novel composition for regulating TGF-beta signaling, as a pharmaceutical composition for cartilage regeneration, as a health food composition for cartilage regeneration, or as a sample composition for cartilage regeneration. 本发明涉及一种包括HAPLN1作为有效成分的用于软骨再生的组合物，根据本发明，HAPLN1蛋白具有促进软骨形成和关节软骨再生的能力，可以通过提高软骨细胞中TGF-β受体I的表达水平来增加具有软骨形成能力的细胞的组成比并诱导软骨组织再生。因此，本发明的HAPLN1蛋白作为用于调节TGF-β信号传导的新型组合物，可有效地用作用于软骨再生的药物组合物、用于软骨再生的保健食品组合物或用于软骨再生的试料组合物。