Iron (III) macrocyclic complexes with mixed hydroxyl pendant groups as MRI contrast agents

The present application describes novel Fe (III) macrocyclic complexes having a hydroxyl pendant group bearing a third anionic helper group for improving in vivo MR imaging. The complex has the following general structure: # imgabs0 #, wherein high-spin Fe (III) is chelated with the complex. Also de...

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Bibliographic Details
Main Authors SNYDER, ELLIOT, M, BURNS PAUL, RAYMOND JENNIFER, MORROW JON R, CASS EDWARD A
Format Patent
LanguageChinese
English
Published 19.03.2024
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present application describes novel Fe (III) macrocyclic complexes having a hydroxyl pendant group bearing a third anionic helper group for improving in vivo MR imaging. The complex has the following general structure: # imgabs0 #, wherein high-spin Fe (III) is chelated with the complex. Also described herein are novel Fe (III) macrocyclic complexes having a hydroxypropyl pendant group bearing a third anionic helper group for improving in vivo MR imaging. Said complexes have the following general structure: # imgabs 1 # 本申请描述新型Fe(III)大环配合物，其具有带有第三阴离子辅助基团的羟基侧基，用于改善体内MR成像。所述配合物具有以下一般结构：#imgabs0#其中高自旋Fe(III)与其螯合。本申请还描述新型Fe(III)大环配合物，其具有带有第三阴离子辅助基团的羟丙基侧基，用于改善体内MR成像。所述配合物具有以下一般结构：#imgabs1#
Bibliography:Application Number: CN202280035671