Compound for degrading Hsp90 based on molecular glue principle, preparation method of compound and application of compound in tumor treatment

• Main Authors: XU JIANHUA, CHEN LONGXI, LIN YOUWEN, JIANG QINGNA, ZHANG YANHONG, WU LIXIAN, FU MINGHAI, TANG YUANLING, LIU YANG
• Format: Patent
• Language: Chinese; English
• Published: 19.03.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to a compound for degrading Hsp90 based on a molecular glue principle, a preparation method of the compound and application of the compound in tumor treatment, the structural formula is shown as X-Y-Z or X-Z, X represents a ligand of HSP90 protein, Z represents a ligand of E3 l...