Compound for degrading Hsp90 based on molecular glue principle, preparation method of compound and application of compound in tumor treatment

The invention relates to a compound for degrading Hsp90 based on a molecular glue principle, a preparation method of the compound and application of the compound in tumor treatment, the structural formula is shown as X-Y-Z or X-Z, X represents a ligand of HSP90 protein, Z represents a ligand of E3 l...

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Bibliographic Details
Main Authors XU JIANHUA, CHEN LONGXI, LIN YOUWEN, JIANG QINGNA, ZHANG YANHONG, WU LIXIAN, FU MINGHAI, TANG YUANLING, LIU YANG
Format Patent
LanguageChinese
English
Published 19.03.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to a compound for degrading Hsp90 based on a molecular glue principle, a preparation method of the compound and application of the compound in tumor treatment, the structural formula is shown as X-Y-Z or X-Z, X represents a ligand of HSP90 protein, Z represents a ligand of E3 ligase, Y represents a chain connecting X and Z. The compound can be used for treating or preventing tumors. 本发明涉及一种基于分子胶原理降解Hsp90的化合物、其制备方法及其在治疗肿瘤中的应用，结构式用X-Y-Z或者X-Z所示，X表示HSP90蛋白的配体，Z表示E3连接酶的配体，Y表示连接X和Z的链，该类化合物可用于治疗或预防肿瘤。
Bibliography:Application Number: CN202310332612