Compound for degrading Hsp90 based on molecular glue principle, preparation method of compound and application of compound in tumor treatment
The invention relates to a compound for degrading Hsp90 based on a molecular glue principle, a preparation method of the compound and application of the compound in tumor treatment, the structural formula is shown as X-Y-Z or X-Z, X represents a ligand of HSP90 protein, Z represents a ligand of E3 l...
Saved in:
Main Authors | , , , , , , , , |
---|---|
Format | Patent |
Language | Chinese English |
Published |
19.03.2024
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | The invention relates to a compound for degrading Hsp90 based on a molecular glue principle, a preparation method of the compound and application of the compound in tumor treatment, the structural formula is shown as X-Y-Z or X-Z, X represents a ligand of HSP90 protein, Z represents a ligand of E3 ligase, Y represents a chain connecting X and Z. The compound can be used for treating or preventing tumors.
本发明涉及一种基于分子胶原理降解Hsp90的化合物、其制备方法及其在治疗肿瘤中的应用,结构式用X-Y-Z或者X-Z所示,X表示HSP90蛋白的配体,Z表示E3连接酶的配体,Y表示连接X和Z的链,该类化合物可用于治疗或预防肿瘤。 |
---|---|
Bibliography: | Application Number: CN202310332612 |