Compositions and methods for enhancing protein production in fungal cells

• Main Authors: KOZAK BARBARA URSZULA, NIKOLAEV IGOR, BARACHON SIMANCAS NATHALIE, PALMER, JOHN, M
• Format: Patent
• Language: Chinese; English
• Published: 15.03.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The present disclosure generally relates to recombinant fungal cells (strains) for commercial scale production of proteins (polypeptides) of interest. Thus, certain embodiments relate to recombinant fungal cells (strains) that produce proteins of interest and overexpress one or more genes encoding regulatory proteins of the present disclosure. 本公开总体上涉及用于商业规模生产目的蛋白(多肽)的重组真菌细胞(菌株)。因此，某些实施例涉及重组真菌细胞(菌株)，这些重组真菌细胞(菌株)产生目的蛋白并且过表达编码本公开的调节蛋白的一种或多种基因。