Methods and systems for mitigating encephalatrophy

• Main Authors: TRAVERS TYLER, WILLIAMS MARTIN, COTTLE CORINNE, SEMENCER, ERIN, MARCHANO, ZACHARY, BOASSO ALYSSA, MROZAK, HOLLY, KONESKY ALEX, MOGRE TOM, QUAN JIN, HEMPEL EVAN, HAJOS, MIHAELA, VAUGHAN BRENT, STROZEWSKI, NATHAN
• Format: Patent
• Language: Chinese; English
• Published: 15.03.2024
• Subjects: DIAGNOSIS; ELECTROTHERAPY; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; MAGNETOTHERAPY; MEDICAL OR VETERINARY SCIENCE; RADIATION THERAPY; SURGERY; ULTRASOUND THERAPY

Systems and methods of the present disclosure are directed to nerve stimulation via non-invasive sensory stimulation. By inducing synchronous gamma oscillations in at least one region of the subject's brain, non-invasive sensory stimulation can reduce neuroinflammation, thereby improving synaptic plasticity and stimulating neural network formation, and improving the clearance of microglia mediated brain injury, which would otherwise contribute to the progression of encephalatrophy. Stimulation may adjust, control, or otherwise manage the frequency of neural oscillations to provide beneficial effects to one or more cognitive states or cognitive functions of the brain while mitigating or preventing adverse consequences on cognitive states or cognitive functions due to encephalatrophy progression. 本公开的系统和方法针对经由无创感官刺激的神经刺激。通过在对象的大脑的至少一个区域中诱导同步伽马振荡，无创感官刺激可以减少神经炎症，从而改善突触可塑性和刺激神经网络形成，并改善小胶质细胞介导的脑损伤的清除，否则其将有助于脑萎缩的进展。刺激可以调整、控制或以其他方式管理神经振荡的频率，以向大脑的一个或多个认知状态或认知功能提供有益影响，同时减轻或防止出于脑萎缩进展而对认知状态或认知功能的不利后果。