Compound for targeted degradation of HSP90 protein as well as preparation method and application of compound

The invention relates to a compound for targeted degradation of HSP90 protein and a preparation method and application thereof, the structural formula of the compound is represented by X-M, X represents a ligand of the HSP90 protein, and M represents a hydrophobic label. The compound can be used for...

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Bibliographic Details
Main Authors XU JIANHUA, CHEN LONGXI, LIN YOUWEN, JIANG QINGNA, ZHANG YANHONG, WU LIXIAN, FU MINGHAI, TANG YUANLING, LIU YANG
Format Patent
LanguageChinese
English
Published 15.03.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to a compound for targeted degradation of HSP90 protein and a preparation method and application thereof, the structural formula of the compound is represented by X-M, X represents a ligand of the HSP90 protein, and M represents a hydrophobic label. The compound can be used for treating or preventing tumors. 本发明涉及一种靶向降解HSP90蛋白的化合物及其制备方法与应用，该化合物结构式用X-M表示，X表示HSP90蛋白的配体，M表示疏水性标签。该类化合物可用于治疗或预防肿瘤。
Bibliography:Application Number: CN202310332615