Brivaracetam sustained-release dry suspension and preparation method thereof

• Main Authors: HUANG DAN, LIU YINGFANG, KE XINGFA, PENG XINBING, GUO ZHIRONG, HUANG YANGBIN
• Format: Patent
• Language: Chinese; English
• Published: 12.03.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the technical field of preparation of pharmaceutical preparations, and particularly discloses a brivaracetam sustained-release dry suspension and a preparation method thereof. The brivaracetam sustained-release dry suspension disclosed by the invention is prepared from sustained-release drug-loaded resin, a suspending aid and a flavoring agent. The brivaracetam dry suspension prepared by carrying a drug through ion exchange resin and then carrying out sustained-release coating has a sustained-release effect, the daily administration frequency can be reduced, and the problems that tablets are difficult to administrate, an oral solution is inconvenient to carry, an injection administration mode is troublesome and the like can be solved by preparing the brivaracetam dry suspension into the dry suspension. 本发明涉及药物制剂制备技术领域，具体公开了一种布瓦西坦缓释干混悬剂及其制备方法。本发明的布瓦西坦缓释干混悬剂由缓释载药树脂、助悬剂和矫味剂组成。本发明通过离子交换树脂载药后进行缓释包衣制备的布瓦西坦干混悬剂，具有缓释作用，可降低每日给药次数，并且制备成干混悬剂也能克服片剂不易给药，口服溶液携带不方便，注射剂给药方式麻烦等问题。