Mycophenolate mofetil gastric adhesion osmotic pump controlled release tablet and preparation method thereof

• Main Authors: SUN SHENGHUA, GUAN YUEQIN, WANG XIULAN
• Format: Patent
• Language: Chinese; English
• Published: 12.03.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the technical field of medicines, and provides a long-acting and high-bioavailability mycophenolate mofetil gastric adhesion osmotic pump controlled release tablet and a preparation method thereof, the mycophenolate mofetil gastric adhesion osmotic pump controlled release tablet comprises: a tablet core, the tablet core comprises mycophenolate mofetil; the surface of the tablet core is coated with the coating layer, and the coating layer contains a gastric mucosa adhesive, so that the tablet is adhered to the gastric mucosa; after the pore-foaming agent is dissolved, holes are formed in the coating layer, so that gastric juice enters the tablet core through the holes, and after the mycophenolate mofetil is dissolved, the mycophenolate mofetil is diffused and released to enter the digestive tract. According to the mycophenolate mofetil gastric adhesion osmotic pump controlled release tablet provided by the invention, the action time of the mycophenolate mofetil gastric adhesion osmotic