Plant carriers, compositions and uses related thereto

• Main Authors: SIMON, AMY, E, XIAO SHU, YANG SHANNON X, YOON JONGCHAN
• Format: Patent
• Language: Chinese; English
• Published: 08.03.2024
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BEER; BIOCHEMISTRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TRAPPING; VINEGAR; WINE

The present disclosure relates to single-stranded RNA vectors suitable for introducing therapeutic agents, such as peptides, proteins or small RNAs, into or otherwise treating host plants. The vectors do not encode any moving protein or coat protein, but are capable of systemic and phloem limited movement and replication within host plants. The vector may be modified to include siRNA effective against bacterial plant pathogens. Alternatively, a wild-type vector may be introduced into a plant to inhibit or control bacterial infections in the plant in a manner of non-specific siRNA produced by RNA silencing or delivery silencing mechanisms of the plant. Optionally, the vector may be modified to include an insert that enhances the silencing mechanism of a plant, such as an insert that is a complement of a plant virus. 本公开涉及单链RNA载体，其适合于将治疗剂如肽、蛋白质或小RNA引入宿主植物或以其他方式治疗宿主植物。所述载体不编码任何移动蛋白或外壳蛋白，但能够在宿主植物内进行全身和韧皮部限制的移动和复制。所述载体可以被修饰为包括对细菌性植物病原体有效的siRNA。可选地，野生型载体可以被引入植物，以通过植物的RNA沉默或传递沉默机制产生的非特异性siRNA的方式来抑制或控制植物中的细菌感染。可选地，所述