Hard shell capsule with improved colon release

• Main Authors: ASSMUS, MANFRED, ROTH, ERNA, BRUNS, JENS
• Format: Patent
• Language: Chinese; English
• Published: 08.03.2024
• Subjects: FOODS OR FOODSTUFFS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY ASINGLE OTHER SUBCLASS; SPECIFIC USE OF COSMETICS OR SIMILAR TOILETPREPARATIONS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

The present invention relates to a method for preparing a polymer coated hard shell capsule wherein the hard shell capsule comprises a body and a cap wherein in a closed state the cap overlaps with the body in a pre-locked state or in a final locked state, wherein the hard-shell capsule is provided in a pre-locked state and is coated with a coating solution, suspension or dispersion comprising or consisting of the following to obtain a coated hard-shell capsule in a pre-locked state: a) at least one (meth) acrylate copolymer a), the (meth) acrylate copolymer a) comprises polymerized units of 5 to 25% by weight of methacrylic acid and 75 to 95% by weight of a C1-to C4-alkyl ester of methacrylic acid and/or a C1-to C4-alkyl ester of acrylic acid; b) 1 to 25 wt.%, preferably 5 to 18 wt.%, based on the total weight of the at least one (meth) acrylate copolymer a), of at least one alkali metal salt or ammonium salt of a saturated aliphatic monocarboxylic acid having 10 to 30 carbon atoms; c) glycerol monostearate