Cyclic peptide and preparation method thereof, complex comprising cyclic peptide and application of cyclic peptide

• Main Authors: LI WENJIE, SHAN CHANGYU, CHEN YINFEI, ZENG DEXING
• Format: Patent
• Language: Chinese; English
• Published: 05.03.2024
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A cyclic peptide is provided, the sequence of which is cyclo (X1X2X3X4X5X6), where X1 is asparagine, X2 is asparagine, X3 is asparagine, X4 is asparagine, X5 is asparagine, and X6 is asparagine. X2 is glycine or sarcosine; x < 3 > is arginine; x4 is selected from the group consisting of threonine, tyrosine, and phenylalanine; the X5 is lysine; and X6 is selected from the group consisting of tyrosine, valine, and glutamic acid. The invention provides a preparation method of a cyclic peptide. Also provided is a complex comprising the cyclic peptide, a linker, and a chelating agent. Provided is a use of a complex as a targeting molecule labeled by radionuclides. A method of labeling a radionuclide is provided, comprising contacting a complex that chelates a radionuclide with a subject to which the radionuclide is to be labeled. 提供了一种环肽，其序列为cyclo(X1X2X3X4X5X6)，其中，所述X1是天冬酰胺；所述X2是甘氨酸或肌氨酸；所述X3是精氨酸；所述X4选自由苏氨酸、酪氨酸、和苯丙氨酸所组成的组；所述X5是赖氨酸；且所述X6选自由酪氨酸、缬氨酸、和谷氨酸所组成的组。提供了一种环肽的制备方法。提供了一种复合物，包括所述环肽、连接子以及螯合剂。提供了一种复合物作为放射性核素标记的靶向分