Preparation method of novel photo-response hydrogel dressing for diabetic wounds

• Main Authors: MA PEIFEN, HU JINGLONG, ZHAO GUANGHUI, LUO JIAYUN, SOPHIA, DA JIANLONG
• Format: Patent
• Language: Chinese; English
• Published: 01.03.2024
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; COMPOSITIONS BASED THEREON; COMPOSITIONS OF MACROMOLECULAR COMPOUNDS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; GENERAL PROCESSES OF COMPOUNDING; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; USE OF INORGANIC OR NON-MACROMOLECULAR ORGANIC SUBSTANCES ASCOMPOUNDING INGREDIENTS; WORKING-UP

The invention discloses a preparation method of a novel photoresponse hydrogel dressing for diabetic wounds. The preparation method comprises the following steps: synthesis of methylacryloyl chitosan, synthesis of nanogold and synthesis of a methylacryloyl chitosan/nanogold/soy isoflavone photoresponse hydrogel dressing. The preparation method has the beneficial effects that the chitosan is subjected to methylacryloylation, so that the chitosan can be quickly subjected to gel state transition in situ on the wound under the action of ultraviolet light, and the characteristics that the diabetic wound surface is easily infected and is delayed to be unhealed are analyzed; nanogold with an antibacterial effect and a soy isoflavone component with the characteristics of resisting oxidation and promoting wound healing are introduced, so that the hydrogel material further has the characteristics of resisting bacteria, resisting oxidation, promoting wound healing and the like on the basis of ensuring the overall biocom