Refining method of valproic acid
The invention discloses a valproic acid refining method, which comprises: adopting diethyl malonate and bromopropane as starting materials, carrying out sodium ethoxide alkylation, strong alkali hydrolysis, strong acid acidification and heating decarboxylation, and distilling to obtain a valproic ac...
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| Main Authors | , , , |
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| Format | Patent |
| Language | Chinese English |
| Published |
01.03.2024
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| Subjects | |
| Online Access | Get full text |
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| Summary: | The invention discloses a valproic acid refining method, which comprises: adopting diethyl malonate and bromopropane as starting materials, carrying out sodium ethoxide alkylation, strong alkali hydrolysis, strong acid acidification and heating decarboxylation, and distilling to obtain a valproic acid crude product; adding the valproic acid crude product into a first organic solvent, adding sodium hydroxide and water into the first organic solvent, stirring, heating, dissolving, cooling and crystallizing; and dissolving the separated solid with a dilute acid solution, adding a second organic solvent for extraction, and washing, drying, concentrating and rectifying the organic phase to obtain refined valproic acid. The prepared valproic acid is good in purity, high in yield, simple and convenient to operate and suitable for industrial large-scale production.
本发明公开了一种丙戊酸的精制方法，包括如下步骤：以丙二酸二乙酯和溴丙烷为起始物料，经乙醇钠烷基化、强碱水解、强酸酸化和加热脱羧后，蒸馏，得丙戊酸粗品；将丙戊酸粗品加入第一有机溶剂中，并向其中加入氢氧化钠和水，搅拌加热溶解，降温析晶；将分离得到的固体用稀酸溶液溶解后，加入第二有机溶剂萃取，有机相经水洗、干燥、 |
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| Bibliography: | Application Number: CN202311781739 |