Synthesis method of atorvastatin calcium intermediate 2-chloro-1-(4-fluorophenyl)-2-acetophenone

• Main Authors: ZHOU TAIYONG, WANG KAI
• Format: Patent
• Language: Chinese; English
• Published: 01.03.2024
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY

The invention relates to a novel synthesis method of an atorvastatin calcium intermediate 2-chloro-1-(4-fluorophenyl)-2-acetophenone, and belongs to the technical field of synthesis, and the specific synthesis method comprises the following steps: adding a solvent, a catalyst and a chlorinating agent into a compound as shown in a formula (3), and reacting at a proper temperature to obtain a compound as shown in a formula (2); adding a solvent, a catalyst and fluorobenzene into the compound in the formula (2), and reacting at a proper temperature to obtain a compound in a formula (1); the preparation method disclosed by the invention is mild in reaction condition, low in cost, safe in process condition, simple in reaction post-treatment and high in product purity, and can fully meet market requirements. 本发明涉及一种阿托伐他汀钙中间体2-氯-1-(4-氟苯基)-2-苯乙酮的合成新方法，属于合成技术领域，具体的合成方法为向式（3）所示的化合物中加入溶剂、催化剂、氯化剂，在适当温度下进行反应，得到式（2）化合物；式（2）化合物中加入溶剂、催化剂、氟苯，在适当温度下进行反应，得到式（1）化合物；本发明所述制备方法反应条件温和，成本低廉，工艺条件安全，反应后处理简单，产品纯度高，能够充分满足市场需求。