SSK1-loaded neurotransmitter derived nano-carrier and application thereof

• Main Authors: LIANG DANQI, LUO YI, ZHANG TINGLIN, YIN YOU, JI WENBO, JI KEQIN, GAO JIE, ZHANG MENGYA, GU YUANKAI, JIANG XIANGHE
• Format: Patent
• Language: Chinese; English
• Published: 01.03.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TESTING

The invention provides an SSK1-loaded neurotransmitter derivative nano-carrier, which is characterized in that the SSK1-loaded neurotransmitter derivative nano-carrier is obtained by mixing SSK1, phenylboronic acid quaternized lipidoid and NT lipidoid, and then carrying out vortex ultrasound and dialysis. The SSK1-loaded neurotransmitter-derived nano-carrier can be used for preparing medicines for treating and relieving symptoms of the Alzheimer's disease. 本发明提供了一种负载SSK1的神经递质衍生纳米载体，其特征在于：该负载SSK1的神经递质衍生纳米载体通过SSK1、苯基硼酸季铵化的类脂质和NT类脂质混合后，经涡旋超声、透析后获得。该负载SSK1的神经递质衍生纳米载体能够用于制备治疗和缓解阿尔茨海默病症状的药物。