Lipid nanoparticle and preparation method thereof

• Main Authors: RYU JI-WON, JANG DA-HYE, LEE TAEWOO, BAEK YU-MI
• Format: Patent
• Language: Chinese; English
• Published: 27.02.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a lipid nanoparticle and a method for preparing the same, and more specifically, to a particle comprising an ionizable lipid and a polyethylene glycol moiety (PEG moiety)-degradable linking functional group-lipid conjugate, characterized by minimizing in vivo side effects and effective transfer of the nanoparticle into a target cell, thereby delivering the pharmaceutically active substance into the cytoplasm. 本发明涉及脂质纳米颗粒及其制备方法，更具体而言，涉及包含可电离脂质和聚乙二醇部分(PEG部分)-可降解连接官能团-脂质缀合物的颗粒，其特征在于最小化的体内副作用以及纳米颗粒至靶细胞中的有效转移，从而将药物有效物质递送至细胞质中。