Inhibitors of ubiquitin-specific peptidase 22 (USP22) and their use for treatment of diseases and disorders

Disclosed are methods of treating diseases or conditions associated with the expression of ubiquitin-specific peptidase 22 (USP22). The disclosed methods are useful for treating diseases or conditions associated with cell proliferation, including cancer. Also disclosed are inhibitors of USP22 that s...

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Bibliographic Details
Main Authors MONTOTTI, ENRICO, GAO, BIN, YAN MING, FANG, DAYONG, DOWN ALAN, LIU HANG
Format Patent
LanguageChinese
English
Published 23.02.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Disclosed are methods of treating diseases or conditions associated with the expression of ubiquitin-specific peptidase 22 (USP22). The disclosed methods are useful for treating diseases or conditions associated with cell proliferation, including cancer. Also disclosed are inhibitors of USP22 that specifically inhibit EC: 3.4.19. 12 activity or thiol-dependent hydrolysis of esters, thioesters, amides, peptides and isopeptide bonds formed by the C-terminal glycine of ubiquitin. The disclosed compounds are also useful in pharmaceutical compositions and methods for treating cell proliferative diseases or disorders associated with USP22 activity. 本发明公开了治疗与泛素特异性肽酶22(USP22)的表达相关的疾病或病症的方法。所公开的方法可用于治疗与细胞增殖相关的疾病或病症，包括癌症。还公开了特异性抑制EC:3.4.19.12活性或由泛素的C端甘氨酸形成的酯、硫酯、酰胺、肽和异肽键的硫醇依赖性水解的USP22的抑制剂。所公开的化合物还可用于治疗与USP22活性相关的细胞增殖性疾病或病症的药物组合物和方法。
Bibliography:Application Number: CN202280036851