Preparation method of avibactam intermediate

The invention provides a preparation method of an avibactam intermediate (2S, 5R)-((benzyloxy) amino) piperidine-2-ethyl formate oxalate, and the preparation method comprises the following steps: reacting N-Boc-(2S, 5S)-hydroxypiperidinecarboxylic acid with bromoethane to obtain 1-(tert-butyl)-2-eth...

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Bibliographic Details
Main Authors HE BAOLIANG, LIU FAGUANG, CHEN SAIHUA, LI DAN, ZHOU AIJUN
Format Patent
LanguageChinese
English
Published 23.02.2024
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention provides a preparation method of an avibactam intermediate (2S, 5R)-((benzyloxy) amino) piperidine-2-ethyl formate oxalate, and the preparation method comprises the following steps: reacting N-Boc-(2S, 5S)-hydroxypiperidinecarboxylic acid with bromoethane to obtain 1-(tert-butyl)-2-ethyl (2S, 5R)-5-hydroxypiperidine-1, 2-dicarboxylate; the preparation method comprises the following steps: taking 2-(tert-butyl)-2-ethyl (2S, 5R)-5-(((2-nitrophenyl) sulfonyl) oxy) piperidine-1, 2-dicarboxylate as a raw material, then reacting with o-nitrobenzenesulfonyl chloride to obtain 1-(tert-butyl)-2-ethyl (2S, 5R)-5-(((2-nitrophenyl) The preparation method comprises the following steps: taking 2-(tert-butyl)-2-ethyl (2S, 5R)-5-((benzyloxy) amino) piperidine-1, 2-dicarboxylate as a raw material, then reacting the 2-(tert-butyl)-2-ethyl (2S, 5R)-5-((benzyloxy) amino) piperidine-1, 2-dicarboxylate with benzyloxy amine in the presence of 1, 4-diazabicyclo [2.2. 2] octane; then removing Boc protection to obtain (2
Bibliography:Application Number: CN202311593573