Methods of controlling infectious diseases with vaccines

The present invention provides a method of eliciting an enhanced immune response in a subject against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) using three incremental doses of a vaccine. The first dose is administered in an amount of 10% to 25% of the total intensity dose of the...

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Bibliographic Details
Main Author WANG DAIYUAN
Format Patent
LanguageChinese
English
Published 20.02.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides a method of eliciting an enhanced immune response in a subject against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) using three incremental doses of a vaccine. The first dose is administered in an amount of 10% to 25% of the total intensity dose of the vaccine. The second dose is used in an amount of 45% to 55% of the total intensity dose of the vaccine 3 to 21 days after the first dose. The final dose is administered in an amount of 100% of the total intensity dose of the vaccine 3 to 21 days after the second dose. The vaccine regimen of the present invention induces the immune response as strong or stronger, and/or for a same length or longer, as compared to a vaccine regimen comprising two or three total intensity doses of the vaccine. In one embodiment, the vaccine is an inactivated viral vaccine. In one embodiment, the vaccine is an mRNA vaccine. 本发明提供了一种使用疫苗的三个递增剂量引发受试者针对严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的增强免疫反应的方法。第一剂量以所述疫苗的全强度剂量的10％至25％的量施用。第二剂量在所述第一剂量之后3至21天以所述疫
Bibliography:Application Number: CN202310015032