Application of glycine hyodeoxycholic acid in preparation of medicine for treating inflammatory bowel disease

• Main Author: CUI YANMEI
• Format: Patent
• Language: Chinese; English
• Published: 20.02.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention relates to the technical field of biological medicines, in particular to application of glycine hyodeoxycholic acid in preparation of medicines for treating inflammatory bowel diseases, including application of glycine hyodeoxycholic acid in preparation of medicines for reducing intestinal mucosal barrier injury. The traditional Chinese medicine composition can effectively relieve the inflammation degree of the inflammatory bowel disease and the epithelial injury condition, and has a good clinical application prospect. The expression of intestinal mucosal barrier related genes and intestinal mucosal barrier molecules can be promoted, the colon length is increased, the weight loss caused by acute enteritis is remarkably relieved, and the pathological injury of colitis is reduced. 本发明涉及生物医药技术领域，尤其涉及一种甘氨猪去氧胆酸在制备治疗炎症性肠病的药物中的应用，包括甘氨猪去氧胆酸在制备降低肠道粘膜屏障损伤药物中的应用。本发明能有效地缓解炎症性肠病的炎症程度和上皮损伤情况，具有很好的临床应用前景。并且能够促进肠道黏膜屏障相关基因以及肠粘膜屏障分子表达，增加结肠长度，显著减轻急性肠炎带来的体重丢失、降低结肠炎的病理损伤。