SYSTEMS AND METHODS FOR ESTIMATING THERAPEUTIC EFFECTS USING COORDINATED VARIABLE ADJUSTMENT LAYERATION

• Main Authors: SCHULER DA COSTA FERRO ANTONIO, MILLER, DAVID, P, VAN DER BEEK ARJAN, LI YUNFAN
• Format: Patent
• Language: Chinese; English
• Published: 09.02.2024
• Subjects: HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; PHYSICS

Systems and methods are illustrated for estimating therapeutic effects using covariate adjustment stratification and pseudo-value regression in random control assays in accordance with embodiments of the present invention. One embodiment includes a method for estimating the efficacy of a treatment in a random control trial, wherein the method includes receiving external data of a previous random clinical trial. The method further includes generating a set of one or more subject characteristics of the plurality of test subjects, estimating binary results of the test subject using a hierarchical process, and estimating a time-of-event (TTE) therapeutic effect of the test subject using pseudo-valued regression. 例示了根据本发明的实施例的用于在随机对照试验中使用协变量调整分层和伪值回归估计治疗效果的系统和方法。一个实施例包括用于在随机对照试验中估计治疗效果的方法，其中该方法包括接收先前随机临床试验的外部数据。该方法进一步包括生成多个试验受试者的一个或多个受试者特征的集合、使用分层过程估计试验受试者的二元结果、以及使用伪值回归估计试验受试者的事件发生时间(TTE)治疗效果。