Preparation for detecting/assisting in detecting autoinflammation-related pericarditis

• Main Authors: CUI YUXIA, SUN SHUANG, SONG JING, SONG ZIQI, ZHAO MEI, CHEN HONG, ZHENG FANGFANG, SONG JUNXIAN
• Format: Patent
• Language: Chinese; English
• Published: 09.02.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

The invention belongs to the technical field of medicines, and provides a preparation for detection/assisted detection of pericarditis, which contains primers for detecting at least one of the following mutation sites of MEFV gene: site 1: p.Leu110Pro; the site 2 is p.Glu148Gln; the site 3 is p.Pro369Ser; and the site is 4: p.Arg408Gln. The preparation provided by the invention can be accurately used for evaluating the recurrence risk and the disease severity of the FMF-related pericarditis, provides effective genetic indexes for evaluating the recurrence risk and the disease severity of the FMF-related pericarditis, and has important scientific and clinical significance. 本发明属于医药技术领域，提供了一种用于检测/辅助检测心包炎的制剂，含有检测MEFV基因的如下至少一个突变位点的引物：位点1：p.Leu110Pro；位点2：p.Glu148Gln；位点3：p.Pro369Ser；位点4：p.Arg408Gln。本发明提供的制剂，可以准确地用于FMF相关心包炎复发风险和疾病严重程度的评估，提供了评估FMF相关心包炎复发风险和病情严重程度的有效遗传学指标，具有重大的科学性和临床意义。