Noradrenaline chemiluminescent probe as well as preparation method and application thereof

• Main Authors: ZHANG LING, ZHAI WENJING, YING WEIWU, LYU LI, YAN DAIYU, JIN SHUANG, XUE YUNSHENG
• Format: Patent
• Language: Chinese; English
• Published: 09.02.2024
• Subjects: ADHESIVES; CHEMISTRY; DYES; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; NATURAL RESINS; ORGANIC CHEMISTRY; PAINTS; PHYSICS; POLISHES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; TESTING

The invention discloses a noradrenaline chemiluminescent probe as well as a preparation method and application thereof. According to the probe disclosed by the invention, 2-chloro-3-hydroxybenzaldehyde and p-methyl thiophenol are selected as main raw materials to construct the near-infrared chemiluminescent probe CL-NE for detecting noradrenaline. The probe has good selectivity, relatively high sensitivity and relatively long chemiluminescence duration time. According to the present invention, the research results show that the chemiluminescence intensity is enhanced along with the increase of noradrenaline, such that the probe is suitable for quantitative detection of noradrenaline; the noradrenaline detection of the cell physiological level and the mouse brain tissue level is realized. More importantly, the probe realizes the detection of noradrenaline in the brain of a Parkinson model mouse. The probe can become an effective tool for monitoring noradrenaline in related nervous system diseases such as Alzhe